Cinco meninas do ensino médio se tornam amigas através do Light Music Club. Yui, a guitarrista principal, Tsumugi é a tecladista, Mio a baixista, Azusa é a guitarrista rítmica e Ritsu, a baterista.

In Toaru Kagaku no Railgun T Mikoto Misaka and her friends prepare for the Daihasei Festival, a seven-day sports competition between different Esper schools, which, of course, also include the Tokiwadai middle school.

A boy whose friend died and became a ghost, starts high school. On his first day, a trunk is sent to him by his brother. From that moment on everyone are after him believing that he holds the mysterious powerful "Asura Machine".